In the presence of DNA damage, ECT2, via its BRCT structural domain, was shown to interact with mitogen-activated protein kinase-associated protein 1 (Sin1), a core component of TOR complex 2, to activate the downstream mTOR complex 2/AKT signaling pathway, stimulating the repair of DNA damage in various cancer and non-cancer cells [27]. Here, MAPKAP1 is linked to cancer.