The pathway analysis of FCD2b.12.u, TSC.7.u, and mTOR.5.u revealed not only impairment of cell metabolism pathways including mitochondria electron transport chain, response to oxidative stress, oxidoreductase complex signaling, ATPase activity, and cellular respiration but also inflammatory response pathways including IL-1 mediated signaling pathways, NF-Kb signaling, T and B cells receptor signaling pathways further demonstrating the tight interplay between energy metabolism and inflammation in epilepsy. The gene discussed is DNAH8; the disease is epilepsy.