RB1 and lung large cell carcinoma: This finding was corroborated by the analysis of 208 lung cancer cell lines from the Cancer Cell Line Encyclopedia (CCLE) [26], where a major upregulation of NFYC-AS1 is observable in SCLC compared to LUAD, LUSC and large cell lung carcinoma (LCLC) cells (Fig. 1G), and in RB1-mut vs -wt cells (Fig. 1H).