Considering SCLC cell line classification into molecular subtypes [25], higher NFYC-AS1 levels were found in neuroendocrine ASCL1 and NEUROD1 groups (Supplementary Fig. S2F), which are characterized by 71% and 90% of RB1-mut cell lines, respectively, as compared to the YAP1 subtype, which has low/absent expression of neuroendocrine markers [27] and comprises only 15% of RB1-mut cell lines. Here, ASCL1 is linked to small cell lung carcinoma.