Remarkably, despite no alterations in the amount of tumor cells per section (Supplementary Fig. 10C), Rapa-CD8CAR cells showed increased infiltration into the tumor mass, as indicated by an increased amount of CAR T cells per section (Fig. 7E), and also accumulated significantly more in tumor islets compared to ctrl-CD8CAR cells, which remained more confined in the few stromal areas (Fig. 7E). The gene discussed is TRERF1; the disease is neoplasm.