The better infiltration of Rapa-CD8CAR into tumor islets was also confirmed by a competition assay upon injection of eFluor670 (eF670)-labelled ctrl-CD8CAR and CFSE-labelled Rapa-CD8CAR cells mixed in a 1:1 ratio into A549-derived lung tumor-bearing NSG mice (Supplementary Fig. 10B). The gene discussed is TRERF1; the disease is neoplasm.