In our study, the addition of exogenous ATP alleviated MB-10-induced inactivation of Akt-mTOR cascade in priBlCa-1 cells, suggesting that reduction in ATP levels could be the primary mechanism underlying the inhibition of the Akt-mTOR cascade by MB-10 in bladder cancer cells (see Fig. 10). This evidence concerns the gene MTOR and urinary bladder carcinoma.