For example, PML isoform IV controls senescence and apoptosis via p53 [15] and cytoplasmatic PML isoforms regulate extrinsic death receptor-mediated apoptosis signaling [16], while the most abundant isoform PML I is associated with angiogenesis in neuroblastoma [17] and PML isoform V serves as structural scaffold of PML nuclear bodies (NBs) [18]. The gene discussed is PML; the disease is neuroblastoma.