CD4 and neoplasm: The density of CD8 + T cells in the tumor area was significantly associated with the percentage of radiographic response (P = 0.0005, Fig. 5a), and so were the densities of M1-like macrophage cells (P = 0.009, Fig. 5b) and CD4 + T cells (P = 0.021, Supplementary Fig. 4A), respectively.