SP1 and Hyperglycemia: Using SwissRegulon tools for regulatory genomics and predicted TF-binding sites,27 we found that SP1 is the TF with the most common binding motif in the promoters of the hyperglycemia-responsive mouse dynein genes (Dync1h1, Dync1i1, Dynll1, and Dctn1, Figure 1A) and their human orthologs (Supplemental Figure 1A), suggesting that SP1 is a key TF that mediates synchronous transcription of dynein genes in diabetes.