Bioinformatics analysis of the promoter sequences of the hyperglycemia-responsive dynein genes identified a shared sequence motif characterized by 5′-GGGGCGGGGC-3′ that binds specificity protein 1 (SP1), a two-cysteine, two-histidine zinc-finger family transcription factor (TF), suggesting a unique role for SP1 in mediating synchronous transcription of these dynein subunits. Here, TF is linked to Hyperglycemia.