It has been shown that alterations in the neural synapse process modify the secretion of EVs vesicles by neurons.29, 30Furthermore, the presence of the most predisposing allele to AD, the APOE-ε4 allele, is related to decreased secretion of brain-derived EVs.31Aß(Amyloid beta) and tau are protein forms known to be involved in the pathophysiology of AD.32, 33Aß is an anomalous insoluble protein formed by the differential cleavage of amyloid precursor protein(APP) by the enzymes β-secretase and γ-secretase in the brain of AD patients. The gene discussed is MAPT; the disease is Alzheimer disease.