Other proposed mechanisms include gene polymorphisms leucine-rich repeat kinase 2 (LRRK2), glucocerebrosidase (GBA), and phosphatase and tensin homolog–induced kinase 1 (PINK1); these have been shown to play a role in lipid regulation and increase the risk for PD in affected individuals [2]. The gene discussed is LRRK2; the disease is Parkinson disease.