Our aims were first to study the association between physical activity and PE in a case-control setting and second to assess whether exercise in pregnant women with and without PE associate with maternal serum concentrations of sFlt-1, PlGF and sEng and sFlt-1/PlGF ratio in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort. The gene discussed is PGF; the disease is preeclampsia.