They showed high expression of PD-1 and T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) with lack of proinflammatory cytokine release and reduced frequency of granzyme B. This impairment of MAIT was attributed to interaction with tumor-associated macrophages expressingprogrammed death-ligand 1 (PD-L1) in adjacent liver cancer areas. This evidence concerns the gene HAVCR2 and liver cancer.