In our 3 cohort meta-EWAS, those pathways were also significantly associated with HIV infection (GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS: whole blood/PBMC q value = 0.000270779; CD4+ T cell: q = 0.00288; GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE, PBMC/whole blood: q value = 0.00027; CD4+ T: q = 0.01; GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION, PBMC/whole blood: q value = 0.000282487). Here, CD4 is linked to HIV infectious disease.