Despite different pathological processes between acute and chronic HIV infection, a few DMPs near genes were the same between those reported by Corley et al. and the current study in monocytes (i.e., IRF7, PRDM16) and in CD4+ T-cells (i.e., KLF7), suggesting a small proportion HIV-associated CpG sites may persist from the acute into the chronic stage of infection. The gene discussed is IRF7; the disease is infection.