For example, in CD4+ T-cells, BCL9 for B-cell acute lymphoblastic leukemia (B-ALL) [44]; GAS7 and PRDM16 for Acute myelogenous leukemia (AML) [45,46]; ESR1 for breast cancer [47]; and GRIN2A for colorectal, lung, and gastric carcinoma [48] were differentially methylated between PWH and PWoH. The gene discussed is PRDM16; the disease is breast cancer.