The 2012 guidelines identify the following indicators for admission: central cyanosis or hypoxemia, severe malnutrition, HIV exposure; other underlying conditions at triage may indicate the need for adapted treatment pathways e.g. prematurity (if still <6 months of age), congenital heart disease and abnormalities (e.g. Trisomy 21, glucose-6-phosphate dehydrogenase (G6PD) deficiency). This evidence concerns the gene G6PD and trisomy 21.