COPS3 knockdown induced cell cycle arrest at G0/G1 phase by upregulating p21 and downregulating CDK4 and cyclin B1 in lung adenocarcinoma cells [20], while COPS5 expression facilitated MDM2-mediated p53 ubiquitination, nuclear export, and degradation [73]. The gene discussed is MDM2; the disease is lung adenocarcinoma.