CARTS traffic specific secretory cargoes, such as pancreatic adenocarcinoma upregulated factor (PAUF) and lysozyme C (LyzC), while exclude others, such as collagen I or vesicular stomatitis virus G-protein (VSVG) (Wakana et al., 2012; Wakana et al., 2013; Wakana and Campelo, 2021; Lujan et al., 2021). This evidence concerns the gene SPACA3 and pancreatic adenocarcinoma.