Shen et al. constructed an immune-related gene signature (DCK,CDK4, BIRC5, IL1RN, SPP1, HSPA4, PSMD2, STC2, PGF, and HSP90AA1), and they found that high-risk HCC patients were more sensitive to 5-Fluorouracil, VX-11e and sapitinib [56]. Here, SPP1 is linked to hepatocellular carcinoma.