Figure 3 provides a phenotypic comparison of AOSLO images for a representative case of a child with RPE65-EOSRD versus RDH12-retinal dystrophy; here the child with RPE65-retinal dystrophy appears to have largely preserved structure, this being one of the reasons why this gene became a successful target for gene supplementation therapy.47 This evidence concerns the gene RPE65 and Retinal dystrophy.