NDE1 and neoplasm: In our study, we discovered that NDE1 promoter methylation was significantly increased in BLCA, BRCA, HNSC, KIRP, LUAD, PRAD, TGCT, THCA and UCEC, while NDE1 promoter methylation was significantly decreased in COAD, ESCA, KIRC, LUSC, PAAD and SARC, suggesting that NDE1 promoter methylation may serve as a critical tumour diagnostic marker.