Furthermore, treatment of <i>Lkb1</i><sup><i>fl/fl</i></sup><i>p53</i><sup><i>fl/fl</i></sup> transgenic mice with linoleic acid for four weeks significantly reduced the growth of endometrial tumors and decreased the expression of VEGF, vimentin, Ki67, and cyclin D1 in tumor tissues. Here, CCND1 is linked to endometrium neoplasm.