FEM1B and Talipes equinovarus: Like FEM1B, it consisted in a severe syndromic developmental disease with autism-like features and a variable set of malformations, including specific abnormalities like septal defect (BAB12522), talipes equinovarus (individual 2) and auto-mutilations and self-harming present in three individuals (BAB12522, individual 1, individual 3).