DNM1 and colorectal carcinoma: Treating CRC clusters with the Src inhibitor Dasatinib or inactivating dynamin through addition of Dynasore and MitMAB strongly block the restoration of an apical-in polarity state, suggesting that Src kinase and dynamin play a role in controlling polarity inversion downstream of β1-integrin engagement with ECM molecules (Okuyama et al., 2016) (Fig. 2).