In enterocytes from individuals with MVID and in Myo5b-mutant CaCo-2 cells, Rab11a-enriched recycling endosomes no longer reach the apical pole, which likely explains the absence of apical determinants at the apical pole (Dhekne et al., 2014; Knowles et al., 2014) (Table 1). Here, MYO5B is linked to microvillus inclusion disease.