SHBG and breast carcinoma: To further validate the predictive ability of SHBG for breast cancer risk, we analyzed SHBG expression in both normal and cancerous breast tissues using data from the Cancer Genome Atlas (TCGA) database and the Genotype Tissue Expression Project (GTEx) database (TCGA: https://portal.gdc.cancer.gov/; GTEx: https://commonfund.nih.gov/gtex).