Six of the most frequent variants of the mtDNA associated with MDs were identified in more than one patient: m.1555A>G in MT-RNR1, m.3243A>G and m.3271T>C in MT-TL1, m.8993T>G in MT-ATP6, m.11778A>G in MT-ND4, and m.13513A>G in the MT-ND5 gene. Here, MT-ND4 is linked to myelodysplastic syndrome.