This study highlighted the effectiveness of sacubitril in improving the outcome of HF (MD=0.49, 95% CI: 0.27-0.89, I2=0%, p=0.02), NT-proBNP (MD = -1.33%, 95% CI: -1.54 to -1.12, I2=96%, p<0.00001), and MACE (MD=0.49, 95% CI: 0.27-0.89, I2=0%, P=0.02). Here, NPPB is linked to hydrops fetalis.