The main findings of this study are as follows: 1) serum prestin levels increase with age in the presence of SNHL; 2) serum prestin levels increase in the presence of mild-to-moderate SNHL, but do not increase further with increased severity of SNHL; and 3) serum prestin levels are positively correlated with PTA for those with mild-to-moderate SNHL. Here, SLC26A5 is linked to sensorineural hearing loss disorder.