Among the components of BBCT, gastrodin of Gastrodiae Rhizoma attenuated amyloid-β (Aβ) deposition and glial activation in the brain of Alzheimer's disease model mice and inhibited abnormal phosphorylation of Aβ and Tau in the hippocampus of VD model rats 19,20. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.