NFE2L2 and Alzheimer disease: Furthermore, Astragalus polysaccharide suppressed apoptosis and Aβ accumulation in an Alzheimer's disease mouse model via the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway, and Atractylodes macrocephala degraded amyloid precursor protein by regulating lysophagy in vitro21,22.