Furthermore, Astragalus polysaccharide suppressed apoptosis and Aβ accumulation in an Alzheimer's disease mouse model via the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway, and Atractylodes macrocephala degraded amyloid precursor protein by regulating lysophagy in vitro21,22. Here, NFE2L2 is linked to early-onset autosomal dominant Alzheimer disease.