AKT1 and urinary bladder carcinoma: Therefore, in contrast to previous studies 9, 10 that hyperoside exerts its anticancer effects through a certain pathway, these phosphorylated MAPK and Akt proteins possess complicated and conflicting downstream signaling pathways, which lead to the ultimate scenario of cell cycle arrest and a small amount of cell apoptosis in T24 bladder cancer cells (Fig. 9).