Additionally, IgM levels were associated with CAD in people without a history of statin use (OR: 0.700, 95% CI [0.552–0.888], P = 0.003), but not in people with a history of statin use (OR: 1.064, 95% CI [0.746–1.519], P = 0.731) after adjusting for age, sex, BMI, smoking status, hypertension, dyslipidaemia, DM, and history of stroke (Fig. 2). Here, CD40LG is linked to stroke disorder.