Gene promoter methylation analysis of the following tumor-suppressors was realized: ATM comprising four evaluated CpG sites (CpG 1–4), PITX2 (CpG 1–5), RASSF1 (CpG 1–3), PTEN (CpG 1–6), and TIMP3 (CpG 1–6) (Figure 6). This evidence concerns the gene TIMP3 and neoplasm.