PITX2 and neoplasm: Gene promoter methylation analysis of the following tumor-suppressors was realized: ATM comprising four evaluated CpG sites (CpG 1–4), PITX2 (CpG 1–5), RASSF1 (CpG 1–3), PTEN (CpG 1–6), and TIMP3 (CpG 1–6) (Figure 6).