In a study of 90 consecutive patients in a crystal arthritis unit, increased levels of interleukin-18 (IL-18), soluble interleukin-6 receptor (sIL-6R), regulated upon activation, normal T cell expressed and secreted (RANTES), leptin and ADPN were found in patients with intermittent gout compared with their controls (Diaz-Torne et al., 2021). Here, IL18 is linked to arthritic joint disease.