NFKB1 and Anxiety: In the Freund’s adjuvant-induced chronic inflammation anxiety mouse model, scopoletin (50 mg/kg, i.p.)exerts an anxiolytic effect through ameliorating anxiety-like behaviors, for which the mechanism is associated with suppression of the NF-κB/MAPK signaling pathways involving anti-inflammatory activities and regulation of the excitatory/inhibitory receptor balance (Luo et al., 2020).