Glucose intolerance ↓, HOMA-IR ↓, serum insulin level ↓, IR ↓, PI3K ↑, GK ↑, G6Pase ↓, SOD ↑, CAT ↑, GPx ↑, H2O2 ↓, and MDA ↓. The gene discussed is PIK3CA; the disease is Glucose intolerance.