EIF2AK2 and cancer: These abnormalities, which have a possibility to impair the effective functioning of viral clearance mechanisms such as interferon (IFN), toll-like receptor (TLR), Janus kinase-signal transducer and activator of transcription (JAK-STAT), and protein kinase R (PKR) pathways, frequently make cancer cells vulnerable to OV invasion and replication, while protecting healthy cells from adverse effects (79).