IL17A and plasma cell myeloma: Then, they further observed that IL-17 promotes myeloma cell growth, colonization, and adhesion to bone marrow stromal cells (BMSC) through blinding to IL-17 receptor, as well as increased the in vivo growth in murine xenotransplantation model of human MM (44).Likewise, the highly significant statistical relationship between the IL-17 in bone marrow and osteoclast formation also strongly supports the promotion of IL-17 to osteolytic disease (45).