Similarly, the IKAROS family zinc finger 1 (IKZF1)- interferon regulatory factor 4(IRF4)/interferon regulatory factor 5(IRF5) axis and the Regulator of G Protein Signaling 12 (RGS12) protein induce myeloma-associated macrophage phenotype switch and functionally skew towards the M1 phenotype, thereby resulting in inhibition of MM growth (131, 132). This evidence concerns the gene RGS12 and plasma cell myeloma.