The latter finding is consistent with previous works showing that OLs constitutively release 2-AG, which promotes OPC proliferation and maturation via autocrine/paracrine activation of CB1R and CB2R, and blockade of CB1R and CB2R decreases OPC maturation in-vitro (16) and exacerbate myelin loss in demyelination mouse models (59–62). The gene discussed is CNR1; the disease is Peripheral demyelination.