In fact, overwhelming data have demonstrated that lots of immunodominant epitopes are found in the prototype of SARS-CoV-2 (Wuhan-Hu-1) and the first generation of COVID-19 Vaccines which developed are based on the S-glycoprotein of SARS-CoV-2 (common epitopes), these common epitopes can activate naïve T cells, which are finally differentiated into memory T cells in persons who are suffered from Wuhan-Hu-1 infection or got COVID-19 vaccination. Here, ART4 is linked to COVID-19.