The two-sample MR analysis showed that the expression of PAFAH1B1, IFNGR1, CDK13, ZZEF1, FNBP4, SLC38A1, UBL3, MT2A, ANP32E, TNIP1, ADAR, MIDN, and E2F4 was potentially associated with the prevalence of AD (Figure 7A). This evidence concerns the gene E2F4 and Alzheimer disease.