After replacing the cohort, FNBP4 (OR = 0.8801; 95% CI, 0.8173–0.9477; p = 0.0007199274) and CHD6 (OR = 0.8785; 95% CI, 0.7797–0.9899; p = 0.0333974294) were found to reduce the risk of AD (Figure 7B). The gene discussed is CHD6; the disease is Alzheimer disease.