Gene enrichment analyses identified key genes, including CDK1, CCNA2, MKI67, TOP2A, FOXM1, EXO1, KIF11, CHEK1, BUB1B, BUB1, GZMA, IL7R, GZMK, CCL5, CCR7, PRF1, TIGIT, CTLA4, KLRB1, and KLRD1 which may modulate T-ALL pathogenesis. Here, KLRD1 is linked to acute lymphoblastic leukemia.