Gene enrichment analyses identified key genes, including CDK1, CCNA2, MKI67, TOP2A, FOXM1, EXO1, KIF11, CHEK1, BUB1B, BUB1, GZMA, IL7R, GZMK, CCL5, CCR7, PRF1, TIGIT, CTLA4, KLRB1, and KLRD1 which may modulate T-ALL pathogenesis. This evidence concerns the gene EXO1 and acute lymphoblastic leukemia.