Gene enrichment analyses identified key genes, including CDK1, CCNA2, MKI67, TOP2A, FOXM1, EXO1, KIF11, CHEK1, BUB1B, BUB1, GZMA, IL7R, GZMK, CCL5, CCR7, PRF1, TIGIT, CTLA4, KLRB1, and KLRD1 which may modulate T-ALL pathogenesis. The gene discussed is TOP2A; the disease is acute lymphoblastic leukemia.