Prostate cancers secrete a variety of factors, such as BMP and endothelin-1 (ET-1), which promote the maturation of osteogenic precursor cells, PTHrP, which inhibits osteoblast apoptosis, aminoproteinases, which indirectly promote bone formation, and urinary fibrinogen activator (uPA) (183). This evidence concerns the gene EDN1 and prostate cancer.