CCL2 and neoplasm: Tumors recruit MDSCs through the CCL2/CCL12-CCR2, CCL3/4/5-CCR5, CCL15-CCR1, CX3CL1/CCL26-CX3CR2, CXCL5/CXCL2/CXCL1-CXCR2, CXCL8 (IL-8)-CXCR1/CXCR2, CCL21-CCR7, CXCL13-CXCR5 pathways, promoting immunosuppression in the TME, while, MDSCs also promote tumor metastasis via the CCL5/CCR5,CCL15-CCR1,CXCL5/CXCL1-CCR2, CXCL8 (IL-8)-CXCR1/CXCR2 pathways (111).