MAOA stimulates the release of IL-6 from osteoblasts, which creates a bone microenvironment conducive to the homing, growth and survival of cancer cells, and also activates osteoclastogenesis through the production of RANKL and IL-6 by osteoblasts, which contributes to the development of bone metastases from cancer (187). This evidence concerns the gene TNFSF11 and cancer.