Furthermore, CXCL5 and colony stimulating factor 1 (CSF-1) are associated with macrophage-driven bone metastasis (87, 93–95) Cyclooxygenase-1 (COX-1) positive macrophages can play an important role in prostate cancer bone metastasis (96) (Figure 1). Here, CSF1 is linked to Familial prostate cancer.