To date, no studies have described the expression of lncRNA in the primary culture of macrophages during the infection with Brucella. Thus, considering our results obtained in RAW264.7 macrophages, the expression of lincRNA-Cox2, Lethe, and lincRNA-EPS, Gas5, and Malat1 was studied in primary macrophages obtained from the peritoneal cavity at 12 h post-infection using RT-qPCR. This evidence concerns the gene GAS5 and infection.