Promotive factors, such as diabetes-induced ROS overexpression, secretion of inflammatory factors, improved conversion rate of aldose reductase (AKR1B1) basement (54), and activation of protein kinase C β, δ, and θ, can accelerate the transformation of stable plaque into unstable plaque or plaque rupture (51, 52), which subsequently leads to thrombosis and the manifestation of adverse coronary events (51). Here, AKR1B1 is linked to diabetes mellitus.