Subsequently, an intersection of 298 module genes associated with CAD as identified by WGCNA combined with 1414 DEGs detected by the “limma” package, 3907 immune_GENEs extracted from MSigDB, and 1567 T2DM DEGs associated with T2DM progression led to the selection of 16 candidate hub genes: PI4KA, YWHAZ, ERRFI1, ABHD17, LRRC40, PLSCR4, NPEPPS, SEL1L3, MAP3K2, ZBED5, EIF2B1, CAPN2, ZNF146, BCHE, UQCRC2, USP34. The gene discussed is CAPN2; the disease is coronary artery disorder.