For instance, in CRC cells expressing activated KRAS, glutaminase, and SLC25A22 promote succinate accumulation, resulting in increased DNA methylation, WNT/β-catenin signaling activation, upregulated leucine rich repeat containing G protein-coupled receptor 5 (LGR5) expression, enhanced proliferation, acquisition of stem cell features, and resistance to 5-fluorouracil [96]. The gene discussed is LGR5; the disease is colorectal carcinoma.