SNCA and adenoma: Notably, hypermethylation of the promoters of genes cannabinoid receptor interacting protein 1 (CNRIP1), fibrillin 1 (FBN1), internexin neuronal intermediate filament protein, alpha (INA), myelin and lymphocyte (MAL), synuclein, alpha (SNCA), and spastic paraplegia 20 (SPG20) was prevalent in CRC (65% to 94%) and adenoma (35% to 91%), whereas normal mucosal samples exhibited minimal methylation (0% to 5%).