Pancreatic adenocarcinoma up-regulated factor (PAUF), a soluble protein associated with pancreatic cancer progression, promotes pancreatic cancer patient-derived MDSC suppressive function via induction of Arg1, iNOS and ROS expression, and this can be reversed through antibody-mediated blockade of PAUF suggesting it as a viable cancer treatment target [85]. This evidence concerns the gene ARG1 and familial pancreatic carcinoma.