Third, IMpower010 clearly showed a direct association between PD-L1 expression and the benefit of ICI, while Keynote-091 did not find a benefit among patients with PD-L1 > 50%, a finding that contradicts the known predictive value of PD-L1 in metastatic stages and a growing body of data suggesting a similar predictive role of PD-L1 in early-stage NSCLC. The gene discussed is CD274; the disease is non-small cell lung carcinoma.