Conventional approaches have only revealed PTENP1 as a regulator of PTEN, but big data has expanded the PTENP1-PTEN interaction to a network module containing several novel PTENP1 interacting partners in the cancer regime, including PTENP1 antisense RNA (PTENP1-AS), RP11-181C21.4, PTENP1-MEMO1P1, and RP11-384P7.7 [31]. Here, PTEN is linked to cancer.