For detailing lncRNA functions, this review provided five lncRNA functional examples that are regulatory network hubs in cancers (Figure 5): growth arrest specific transcript 5 (GAS5), small nucleolar RNA host gene 12 (SNHG12), taurine up-regulated 1 (TUG1), HOX transcript antisense RNA (HOTAIR), and phosphatase and tensin homolog (PTEN) pseudogene 1 (PTENP1). The gene discussed is PTEN; the disease is cancer.