In line with KIR+CD8+ Tregs in patients with autoimmune diseases, the predicted-reactive KIR+CD8+ T cell population we observed highly expressed genes encoding several members of inhibitory KIRs (KIR2DL1, KIR2DL3, KIR3DL1, KIR3DL2) in addition to cytotoxic molecules (GZMB, PRF1, GNLY) and cell trafficking proteins (CX3CR1, CCL4, CCL5, ITGB1) hypothesized to be involved in their regulatory function. Here, PRF1 is linked to autoimmune disease.