Consistent with previous studies7, circulating CD8+ T cells clonally related to tumor-infiltrating T cells had high expression of genes related to cytotoxicity (GNLY, GZMB, FGFBP2) and cell migration (ITGB1) regardless of predicted reactivity (Fig. 2B, table S5–6). This evidence concerns the gene FGFBP2 and neoplasm.