Although in our proteomic dataset, most of these calcium signaling-related proteins were not significantly different among these three AD phenotypes, proteins related to activation of NMDAR and post synaptic signaling transmission were significantly up-regulated in controls vs SAD including glutamate ionotropic receptor AMPA type subunit 1–3, GRIA1–3 (AMPAR), voltage-dependent calcium channel gamma-2–4, CACNG2–4 (VGCC), PKC alpha binding protein (PICK1), and Calcium/calmodulin-dependent protein kinase type IV (CAMK4) (Fig. S12c). This evidence concerns the gene PICK1 and Alzheimer disease.