Interestingly, our correlation analysis (Fig. S13b-c) showed that LPE 22:6 has a negative correlation to PPP1R1A (cor=-0.58, p = 0.0015) and a positive correlation to PPP1CA (cor = 0.28, P = 0.16), suggesting a possible role of LPE 22:6 in AD development. This evidence concerns the gene PPP1CA and Alzheimer disease.