Of the kinase inhibitor gene targets evaluated, high pre-treatment PIKFYVE, KDR, NTRK1, IKBKB, FLT1, or FGFR1 expression was each associated with lower odds of achieving CR when controlling for cancer type, biopsy site, age at the time of treatment initiation, and ICB agent (Fig. 1c). This evidence concerns the gene IKBKB and cancer.