β2AR expression was lost early in plaque-associated microglia but plaque-distal microglia expressed control levels of β2AR at 4 months which decreased to the levels seen in plaque-associated microglia by 6 months (Supplementary Fig. 4c), suggesting that amyloid pathology also affected β2AR expression in CX3CR1 haploinsufficient animals. Here, CX3CR1 is linked to amyloidosis.