SHBG and alcohol dependence: There was no genetic correlation of alcohol dependence with SHBG in females (rg = −0.0206, p = 0.7006) or males (rg = 0.0670, p = 0.1802); however, alcohol dependence trended toward positive genetic correlation with BMI-adjusted SHBG in males (rg = 0.1185, p = 0.0174) but not in females (rg = 0.0258, p = 6128) (Table 2).